Impairment of context memory by β-amyloid peptide in terrestrial snail

Impairment of context memory by β-amyloid peptide in terrestrial snail

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We examined influence of the β-amyloid peptide (25-35) neurotoxic fragment (βAP) on Helix lucorum food-aversion learning.Testing with aversively conditioned carrot showed that 2, 5, and 14 days after training the βAP-injected group responded in a significantly larger number of cases and with a significantly smaller latency than the sham-injected control group.The results demonstrate that the amyloid peptide partially impairs the learning process.In an attempt to specify what component of memory is impaired we compared responses in a context in which the snails were aversively trained, and in a neutral rubbermaid 8 gallon trash can context.

It was found that the sham-injected learned snails significantly less frequently took the aversively conditioned food in the context in which the snails were shocked, while the βAP-injected snails remembered jilungin dreaming tea the aversive context 2 days after associative training, but were not able to distinguish two contexts 5, and 14 days after training.In a separate series of experiments a specific context was associated with electric shock, and changes in general responsiveness were tested in two contexts several days later.It was found that the βAP-injected snails significantly increased withdrawal responses in all tested contexts, while the sham-injected control animals selectively increased responsiveness only in the context in which they were reinforced with electric shocks.These results demonstrate that the β-amyloid peptide (25-35) interferes with the learning process, and may play a significant role in behavioral plasticity and memory by selectively impairing only one.